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J.Jpn. Surg. Soc.. 124(2): 157-162, 2023

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Department of Gastroenterological Surgery I, Hokkaido University, Sapporo, Japan

Masafumi Ohira, Akinobu Taketomi

The global population of individuals with diabetes continues to grow, with an estimated 10 million patients in Japan. Diabetes is known to be associated with the risk of various complications such as microangiopathy as well as a significantly higher risk of developing various types of cancer compared to nondiabetic individuals. It has been reported that several molecular mechanisms may be involved, including oxidative stress caused by hyperglycemia, the PI3K/Akt pathway caused by hyperinsulinemia, and many other molecular mechanisms associated with obesity. Moreover, the association between diabetes and cancer is not unidirectional; an increased risk of developing diabetes due to cancer has also been reported, suggesting that diabetes and cancer are interrelated through very complex mechanisms. In addition, the possibility that antidiabetic drugs may have anticancer effects has been reported in recent years, and many clinical trials are currently underway. In daily practice, we should always treat patients with this very complex relationship between cancer and diabetes in mind and continue to conduct new basic and clinical research to elucidate this relationship.

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