J.Jpn. Surg. Soc.. 119(4): 401-407, 2018

---

Feature topic

INTESTINAL ORGANOID APPLICATIONS IN REGENERATIVE MEDICINE

In the last decade, significant progress has been made in culturing intestinal epithelial cells in vitro as various forms of intestinal organoids, which are 3D cell cultures that contain a self-renewing epithelial stem cell population capable of differentiating into multiple intestinal cell types. As these intestinal organoids recapitulate many aspects of the intestine in vivo, there is growing interest in using them as a source for regenerative medicine. One such approach would be to prompt organoid cells to mature into tissue-engineered small intestine by implanting them into hosts with synthetic scaffolds. Another strategy for using organoid cells in the treatment of intestinal diseases would be their direct transplantation into the native intestines of recipients. Future progress in this research field could lead to the development of therapeutic options to use different types of organoids with various cell types in regenerative medicine for the treatment of intestinal diseases in humans.

---

---

To read the PDF file you will need Adobe Reader installed on your computer.