J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 2834KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 105(4): 309-313, 2004

Editorial

PROTECTIVE EFFECT OF CARBON MONOXIDE FOR ORGAN INJURY

1) Thomas E Starzl Tranzplantation Institute, University of Pittsburgh
2) First Department of Surgery, Okayama Medical School
3) Division of Organ Replacement Research, Center for Molecular Medicine, Jichi Medical School

Atsunori Nakao1)2), Eiji Kobayashi3), Noriaki Tanaka2), Noriko Murase1)

Heme oxigenase (HO) catabolizes heme into three products: carbon monoxide (CO), biliverdin and free iron. HO-1, inducible form of HO, has been shown to be protective against various stress. CO at a low concentration has been shown to be protective in several disease models mimicking the action of HO-1. We suggest that CO, the byproduct of heme degradation, could be valuable therapeutic agents. We review the functional role of HO-1 and CO and its potential application to clinical settings.

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