J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 740KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 104(6): 488-490, 2003

Case report

A CASE WITH POORLY DIFFERENTIATED FOLLICULAR CARCINOMA OF THE THYROID PRODUCED AND SECRETED CEA

1) Department of Surgery, Kuma Hospital, Kobe, Japan
2) Second Department of Pathology, Wakayama Medical College, Wakayama, Japan

Kaoru Kobayashi1), Tamotsu Yokozawa1), Yasuhiro Ito1), Humio Matsuzaki1), Kanji Kuma1), Akira Miyauchi1), Kenichi Kakudo2)

Detection of thyroglobulin, CEA, and calcitonin in serum and tissue is very useful to make differential diagnosis among papillary, follicular, and medullary carcinoma of the thyroid.
The case was a 70-year-old woman with a nodule of the thyroid, presenting elevated serum level of thyroglobulin and CEA (22.0ng/ml). Both serum level of thyroglobulin and CEA decreased after surgery. One year and nine months after surgery, she died from systemic metastases of thyroid carcinoma.
Histological examination of the tumor presented to be poorly differentiated type of follicular carcinoma presenting positive of both thyroglobulin and CEA, and negative of calcitonin in the cytoimmunochemistry.
This case was identified to be a rare case that tumor cells of poorly differentiated follicular carcinoma produced and secreted both thyroglobulin and CEA.

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