J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 2077KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 103(2): 250-255, 2002

Feature topic

HEAVY-ION THERAPY FOR NON-SMALL CELL LUNG CANCER

1) Radiation Oncology, Research Center of Charged Particles, National lnstitute of Radiological Sciences, Chiba, Japan
2) Respiratory Surgery, Department of Medicine, Chiba University, Chiba, Japan
3) Department of Radiology, Kobe University School of Medicine, Kobe, Japan

Tadaaki Miyamoto1), Naotaka Yamamoto1)2), Masashi Koto1), Hideki Nishimura3), Hirohiko Tsujii1), Takehiko Fujisawa2)

Since carbon beam therapy for non-small cell Iung cancer (NSCLC) was initiated in October 1996, seven trials have been conducted ; three have already closed and the remaining four are ongoing The local control rate cause-specific survival rate, and overall survival rate of 141 patients with clinical stage I NSCLC were 82%, 58%, and 42%, respectively. Radiation pneumonia was rare (2.1%) and not serious. In the phase II clinical study, the local control rate achieved in 50 patients was 100%, with no radiation pneumonia, resulting in a 60% overall survival rate. Carbon beam therapy could be an alternative to surgery, especially for lung cancer patients of advanced age and/or with complications.
For locally advanced lung cancer treated with carbon beam therapy, excellent local control comparable to that in stage INSCLC has been demonstrated and offers hopeful prospects for the treatment of lung cancer.

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