J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 965KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 99(10): 687-695, 1998

Feature topic

GENETIC ALTERATIONS IN GALLBLADDER CARCINOMA：A REVIEW

1) Department of Pathology, Niigata University School of Medicine, Niigata, Japan
2) Department of Surgery, Niigata University School of Medicine, Niigata, Japan
3) Department of Pathology, Tokai University School of Medicine, Isehara, Japan

Naoyuki Yokoyama1)2), Hidenobu Watanabe1), Yoichi Ajioka1), Ken Nishikura1), Kazutoshi Date1)2), Hiroshi Kijima3), Yoshio Shirai2), Katsuyoshi Hatakeyama2)

Earlier evidence suggests that gallbladder carcinoma (GBC) has three carcinogenic pathways : de novo development；adenoma-carcinoma sequence；and hyperplasia-carcinoma sequence associated with an anomalous arrangement of the pancreaticobiliary duct (AAPBD). We review gene abnormalities in GBC reported to date. p53 mutation and its protein overexpression are frequently observed in de novo carcinoma and GBC with AAPBD, but never found in carcinoma with adenoma. The incidence of K-ras codon 12 mutation in GBCs with AAPBD is significantly higher than that in the other types. Mutation of K-ras is nerver detected in carcinoma with adenoma. These findings suggest that diverse genetic pathways may exist in gallbladder carcinogenesis and reflect morphologic variations.

To next page >>

To read the PDF file you will need Adobe Reader installed on your computer.