J.Jpn. Surg. Soc.. 98(7): 649-654, 1997

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SURGICAL TREATMENT AND RESEARCH OF ESOPHAGEAL CANCER IN THE PAST AND THE PRESENT ERA IN OUR DEPARTMENT -FOR THE VIEW POINT OF THE FUTURE-

We describe the result of esophageal cancer treatment in the past era of the Department of Surgery, Chiba University School of Medicine directed by Professor Seo, Nakayama and Sato and the improved results of the treatment at the present time from the view point of diagnosis (early superficial cancer, Iymph node metastasis and adjacent organ invasion) and treatment (three-field Iymph node dissection, improved result of operative mortality and morbidity, improvement of Iong-term survival rate). In addition, we prospect the future through the present study such as mutation of P53 gene and malignancy, immunotherapy using cytokine gene transfer, cancer inhibition therapy by induction of cancer suppressor gene, prodrug therapy, heavy particle iron therapy, and clinical application of virtual reality to the surgical field.

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