J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 2575KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 98(5): 472-478, 1997

Feature topic

MODE OF SPREADING AND BIOLOGICAL BEHAVIER IN BILE DUCT CARCINOMA

Second Department of Surgery, Yokohama City University, Yokohama, Japan

Atsushi Takimoto, Itaru Endo, Yasushi Ichikawa, Takashi Ishikawa, Shinji Togo, Hiroshi Shimada

There are three macroscopic types of hepatic bile duct carcinoma, such as papillary (P-), nodular (N-) and diffuse (D-) type. Immunohistochemical studies demonstrated that P-type expressed cadherin and catenin higher than N- and D-types. The expressions of both cadherin and catenin were found stronger in pap and tub1 than tub2. The nuclear area of cancer cell, correlated with both labeling index of Ki-67 and aberrant accumulation of p53, was significantly larger in the subserosal layer than in the mucosal layer. These may explain the differences in the biological behavior between P- and N, D-types. P-type grows within the mucosal layer, while N-and d-type are more invasive, developing into the subserosal layer.
Our clinical data also demonstrates the poor prognosis of N-, D-type of hepatic bile duct carcinoma. On these basis of the biological malignancy of N, D-type, it is critical to remain the surgical margin free from cancer cells to cure this type of hepatic bile duct carcinoma.

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