J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 2826KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 97(9): 708-715, 1996

Feature topic

Cytokines in Surgical Stress

1) Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan
2) Department of Bacteriology, School of Medicine, Iwate Medical University, Morioka, Japan
3) Department of Surgery I, School of Medicine, Iwate Medical University, Morioka, Japan
4) Department of Anesthesiology, School of Medicine, Iwate Medical University, Morioka, Japan

Shigetasu Endo1), Katsuya Inada2), Nobuhiro Sato3), Takae Kawamura4)

The systemic inflammatory response is seen in assosiation with various clinical conditions. Tumor necrosis factor, or other cytokines play an important role in systemic inflammatory response syndrome (SIRS). A frequent complication of SIRS is the development of organ system dysfunction, such as ARDS, DIC, renal failure, shock, and multiple organ dysftmction. Inflammatory cytokines become a trigger for the production of phospholipase A2, eicosnoids, NO, endothelin-1, thrombomodulin, polymorphonuclear leukicyte, and adhesion molecules. These mediators cause complex pathophysiologic condition in SIRS.
In this study, we discuss a role of cytokines in surgical stress, hemorrhagic shock, burns, and septic shock.

<< To previous pageTo next page >>

To read the PDF file you will need Adobe Reader installed on your computer.