J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 3487KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 97(5): 375-380, 1996

Feature topic

GENETIC ALTERATIONS AND DNA-BASED DIAGNOSIS IN BREAST CANCER

1) Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, Kawasaki, Japan
2) Department of Surgery, Cancer Institute Hospital, Tokyo, Japan
3) Laboratory of Molecular Medicine, Institute of Mcdical Science, The University of Tokyo, Tokyo, Japan

Satoshi Matsumoto1), Mitsuru Emi1), Fujio Kasumi2), Yusuke Nakamura3)

Human carcinomas are generally considered to develop through the accumulation of various genetic abnormalities. The major types of genetic alterations that are frequently observed in breast cancer are amplification of protooncogenes (MYC, ERBB2) ; mutation of TP53 ; and loss of heterozygosity on chromosomes 1, 3p, 8p. 11p, 13q, 17q, 17, and 22q. The latter may correspond to losses or inactivations of tumor suppressor genes. Recently, two major distinct breast susptibility genes were isolated, namely BRCA1 and BRCA2. We performed PCR-SSCP analysis to determine the role of the BRCA1 gene in Japanese breast cancer and investigated how multiple genetic alterations contribute to tumor development and/or progression in primary breast cancer, using a large number of tumor materials.

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