J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 3663KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 97(1): 21-26, 1996

Feature topic

THE PATHOGENESIS OF IDIOPATHIC PORTAL HYPERTENSION

1) The Department of Pathology, Juntendo University School of Medicine, Tokyo, Japan
2) The Division of Medicine, Institute of Gastroenterology, Tokyo Women's Medical College, Tokyo, Japan
3) The Division of Surgeruy, Juntendo University School of Medicine, Tokyo, Japan

Katsutoshi Tokushige1)2), Katsumi Yamauchi2), Naoki Hayashi2), Shinji Futagawa3), Sachiko Hirose1), Toshikazu Shirai1)

Idiopathic portal hypertension (IPH), so called Banti’s disease, is characterized by anemia, splenomegaly and portal hypertension. While sharing certain clinical features, IPH is distinct from liver cirrhosis not only in histopathology and natural history but also in vascular anatomy and portal hemodynamics. Our studies have shown that the majority of patients with IPH have high serum levels of immunoglobulins, including autoantibodies, associated with abnormally high frequencies of activated T cells and the biased usage of particular T cell receptor (TCR) Vβ gene segments. These results suggested that IPH was an immunological disorder mediated by a continuous stimulation with either a certain antigen or more likely a superantigen.

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