[
Abstract]
[
Full Text PDF] （in Japanese / 1019KB）
[Members Only And Two Factor Auth.] J.Jpn. Surg. Soc.. 96(10): 685-694, 1995
Original article
STUDIES OF LIVER MACROPHAGE FUNCTION IN THE INTRAABDOMINAL INFECTION AFTER PARTIAL HEPATECTOMY IN THE RAT MODEL
The activities of superoxide (O
2-), tumor necrosis facter (TNF) and interleukin-1 (IL-1) of rat liver macrophage (Mφ) were studied in the condition of intraabdominal infection (E group), hepatectomy (H group) and intraabdominal infection following hepatectomy (HE group). In the early stage of E and HE groups, O
2-production was significantly increased after infection. In the H and HE groups, O
2- production was significantly increased at 48 hours after hepatectomy, probably due to liver regeneration. In every group, the changes of TNF activity showed the similar pattern to those of O
2- production. In H and E groups, the elevation of IL-1 activities was significantly incarased. Howerve in HE group, the IL-1 level remained low during 72 hours.
When the Mφ 48 hours following hepatectomy was stimulated by lipopolysaccharide (LSP), activities of TNF and IL-1 were correlated and reversely correlated with the LPS level, respectively.
In the excessive stimulation by infection followng hepatectomy, IL-1 activity is significantly suppressed with production of O
2- and TNF by Mφ mainatined.
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