J.Jpn. Surg. Soc.. 96(7): 430-438, 1995

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Original article

THE CHANGE OF POLYMORPHONUCLEAR ELASTASE RELEASING FROM ISCHEMIC SKELTON MUSCLES AFTER REPERFUSION

This report evaluates the activity of Polymorphonuclear Elastase (PMNE), after reperfusion of the skelton muscles during the infra-renal abdominal aortic aneurysmal surgery. We studied the following data to prevent post-operative complications of acute arterial occlusion : the change of PMNE and α₁-AT and the effect of Ulinastatin (U)- the inhibitor of PMNE. Twenty surgical cases of the abdominal aortic aneurysms were used in the study. Ten cases of non-U-treated served as group I, 10 cases of U-treated served as group II. PMNE level, in group I, showed a value of 233.7±34.8μg/l pre clump and 848.0±110.3μg/l after releasing the clamp 2 hours later (p< 0.001). In group II, pre-clamping value was 204.8±21.0 and a relative low value of PMNE (416.7±36.6μg/l) 2 hours later after releasing the clamp compared with group I. In group I, consistently positive correlations were found between the duration of clamping time and the value of PMNE. This study shows that PMNE increases statistically after re-perfusion of the skelton muscle. U shows a significant inhibition of PMNE increasing. U may prevent further damages of the visceral organs after operation of acute arterial occlusion.

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