J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 4025KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 96(1): 10-18, 1995

Original article

ROLES OF MYOFIBROBLASTS IN THE STROMA OF HUMAN GASTRIC CARCINOMA

1) Department of Surgery The Second Hospital, Nippon Medical School, Kawasaki, Japan
2) Department of Pathology, Nippon Medical School, Tokyo, Japan

Masanori Watanabe1)2), Toshikazu Hirano2), Goro Asano2)

The stromal reaction of human gastric carcinoma was studied about myofibroblast proliferation and collagen type I, III synthesis in 28 surgical materials (15 cases of well differentiated type, 13 cases of poorly differentiated type), using immunohistochemical and immunoelectron microscopical techniques.
Immunohistochemically, myofibroblasts showed marked reactivity to both anti-α smooth muscle actin (αSM-1) MAb and anti-vimentin MAb, and they were broadly distributed in the stroma of gastric carcinomas. Morever, myofibroblasts revealed their own characteristics surrounding collagenous fibers under electron microscope.
The myofibroblast proliferation was more prominent in poorly differentiated carcinoma and invasive carcinomas. On the other hand, much more myofibroblasts were observed in the marginal portion of cancer nests than the central area. The distribution of collagen type III was very similar to that of myofibroblast.
These findings suggest that the proliferation of myofibroblast and collagen synthesis in tumor stroma were obvious host response against carcinomas, and this phenomenon may reveal an important biological status in gastric carcinoma.

<< To previous pageTo next page >>

To read the PDF file you will need Adobe Reader installed on your computer.