J.Jpn. Surg. Soc.. 95(12): 899-910, 1994

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Original article

DEVELOPMENT OF NOVEL ELASTOMERIC SURGICAL ADHESIVE: BIOMECHANICAL AND PATHOHISTOLOGICAL HEELING PROCESS

A newly developed novel elastometric surgical elastoma based on reactive hydrophylic urethane was tested in vivo experiment of dog models for its anastomotic performances and functions at various periods. The carotid artery as well as the abdominal aorta were completely transected and re-anastomosed by applying the adhesive materials.
The serial studies on patency rate, tensile strength, elasticity as well as histopathological examinations were undertaken up to the longest period of 180 days after the implantation.
The overall patency rate in carotid anastomasis was 93.9%, where in the abdominal aorta, 100% of patency rate was obtained. The tensile strength at the anastomosis surpassed the stress derived from pulsation and internal tention within 7 days of implantation. No significant change in stiffness parameter β was observed in 180 days of implantation.
Histopathological studies at the site of anasotmosis revealed the presence of mild inflammatory reaction in earlier phase and well healing of tissue without foreign body reaction in later period.
This material proved to be an effective surgical adhesive in reference to the compliance mateching so as to facilitate to expect for the clinical application in cardiovascular surgical practice.

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