J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 1269KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 95(10): 753-762, 1994

Original article

EXPRESSION AND PROGNOSTIC INDICATORS OF TYPE 1 AND TYPE 2 LEWIS BLOOD GROUP ANTIGENS IN COLORECTAL CANCERS

1) Department of Surgery II, Nagoya University School of Medicine, Nagoya, Japan
2) Nanakuri Sanatorium, Fujita Health University, Mie, Japan
3) Aichi Cancer Center Hospital, Nagoya, Japan

Shuji Asai1), Tadashi Watanabe2), Junichi Sakamoto3), Kozo Kiriyama1), Katsuki Ito1), Seiji Akiyama1), Hiroshi Takagi1)

The immunohistochemical analysis using the monoclonal antibodies to the blood group antigens was performed on the tissues of 387 colorectal cancers and 307 normal colonic tissues, and the relation between expression of these antigens and prognosis of the patients with stage 2 was also investigated. La, Leb, and CA 19-9 were used for type l antigens, and Lex, Ley, and Sialyl Lex for type 2, respectively. Expression of Ca 19-9 and Silyl Lex remarkably increased in cancers throughout the colorectum. Leb and Ley were expressed in only 0-17% of the normal distal colon, but in almost colonic tumors. Therefore CA 19-9 and Sialyl Lex are tumor-associated antigens in the whole colorectum, and Leb and Ley in the distal colon. Experssion of CA 19-9 in primary tumor provided more prognostic information and risk of liver metastasis than other Lewis blood group antigens.

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