J.Jpn. Surg. Soc.. 95(10): 743-752, 1994
Original article
A ORNITHINE DECARBOXYLASE ACTIVITY AND PROLIFERATING CELL NUCLEAR ANTIGEN IN GASTRIC CANCER
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The First Department of Surgery, Fukushima Medical College, Fukushima, Japan Yutaka Hoshino, Yasushi Teranishi, Shinya Terashima, Fujio Ito, Akira Konno, Hitoshi Inoue, Ryoichi Motoki |
ODC activity was 473.3±54.7 pmol CO2/60 min/mg protein in tumors, and 273.5±38.3 pmol CO2/ 60min/mg protein in normal mucosa. ODC activity in tumors was significantly higher than that of normal mucosa. ODC activity in tumors was significantly high in gross type 4, maximum diameter more than 10 cm, depth se, infiltrative growth (INF) γ, positive lymph vessel invasion and positive lymph node metastasis.
PCNA-LI was 24.7±1.5% in tumors, and 13.9±1.1% in normal mucosa. PCNA-LI of tumors was significantly higher than that of normal mucosa. PCNA-LI of tumors was significantly high in gross type 2, histological type tub 2 and por, depth ssβ and se, IFNβ, positive lymph vessel invasion, positive venous invasion, and positive lymph node metastasis.
ODC activity and PCNA-LI were closely related in normal mucosa, showing a correlation coefficient of 0.730. On the other hand, their relationship was weak in tumors, showing a correlation coefficient of 0.417. These results suggest the differentiation of value between ODC activity and PCNA-LI in gastric cancer.
In gastric cancer, ODC activity and PCNA-LI in tumors may be good markers of lymph node metastasis. Furthermore, PCNA-LI may be a good marker of hematogenous metastasis.
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