J.Jpn. Surg. Soc.. 95(8): 512-520, 1994
Original article
AN EXPERIMENTAL STUDY OF HYPERTHERMOCHEMOTHERAPY WITHOUT OXYGENATION BY ISOLATED LIVER PERFUSION
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First Department of Surgery, Nara Medical University, Kashiwara, Japan Masato Horikawa, Yoshiyuki Nakajima, Hiromichi Kanehiro, Hiroshige Nakano |
The isolated liver perfusion was performed at the rate of 75-100ml/min through the portal vein for 30min under the V-V bypass. Experimental groups were divided as following; Croup I (n=5):The perfusate was lactate Ringer's solution without oxygenation and kept at 42°C. Group II (n=5), Mitomycin C (10μg/ml) was added to the perfusate used in Group I.
During the perfusion the liver temperature was kept at 41°C. PH of the liver tissue and AKBR returned quickly to preperfusion level after liver perfusion. In the both groups, GOT, GPT, ALP were elevated, and returned to normal range within 14 days, although GPT was significantly high until the 5th day in Group II compared with Group I. In the values of amylase, BUN and Cr., no remarkable changes were observed, and any histologic damage of the liver and other organs was not found on day 14.
In conclusion, this new hyperthermochemotherapy system could be a simple and safe method, and should be applicable for clinical cases.
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