J.Jpn. Surg. Soc.. 95(3): 162-170, 1994

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Original article

AN EXPERIMENTAL STUDY ON MOTILITY OF ISOLATED JEJUNAL SEGMENT : WITH SPECIAL REFERENCE TO THE RELATION TO THE INTESTINAL BLOOD FLOW AND ACETYLCHOLINE ESTERASE ACTIVITY IN THE ENTERIC PLEXUS

Regurgitation of liquids at swallowing is known to occur at an early stage after free jejunal transfer for replacement of the cervical esophagus. To clarify a part of the mechanism, intestinal motility of isolated segment was studied in mongrel dogs with special reference to the relation to intestinal blood flow of the isolated jejunal segment increased with the lapse of time. Ach-E activity determined by histochemical examination decreased remarkably after one week and recovered thereafter reaching the level of control after 6 weeks. Intestinal motility of the segment was monitered by strain gauge force transducer. Continuous high amplitude contractions similar to those seen during feeding appeared 2-3 weeks after the conduction of isolated segment, but migrating motor complex (MMC) withan intervening period of quiscence occurred and propagated across the area of reanastomosis after 6 weeks.
Consequently, intestinal blood flow and Ach-E activity in the enteric ploxus were suggested to relate to the motility of the isolated intestinal segment. Continuous high amplitude contractions may be involved in the pathophysiology of swallowing disturbance occurring at an early stage after free jejunal transfer for replacement of the cervical esophagus in clinical cases.

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