[
Abstract]
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J.Jpn. Surg. Soc.. 94(10): 1071-1077, 1993
Original article
CHANGES OF SERUM INTERLEUKIN 6 (IL6) AND ACUTE PHASE PROTEIN AFTER HEPATECTOMY IN PATIENTS WITH CHRONIC LIVER DISEASE
We examined the changes in serum levels of interleukin 6 (s-IL6) and acute phase protein (APP) during perioperative periods in patients with or without chronic liver disease (CLD) who underwent hepatectomy or other surgeries. The elevation of s-IL6 on the first postoperative day was only correlated with preoperative values of indocyanine green retention test (ICG-R15) (r=0.56, p<0.01), and not concerned with any operative factors.
We devided the patients into the following three groups; the patients with CLD undergoing hepatectomy (n=21, group A), the patients without CLD undergoing hepatectomy (n=7, group B), and the patients without CLD undergoing surgeries other than hepatectomy (n=7, group C). The values of s-IL6 on preoperative day, 1st, 4th, and 7th days after surgery in group A were significantly higher than the corresponding values in group C (p<0.05).
Among the hepatectomy groups, the serum levels of APP on the 4th day after surgery were significantly higher than those on preoperative day.
We concluded that the changes in s-IL6 after hepatectomy were strongly concerned with preoperative liver function, especially with values of ICG-R15. However, it seemed that the induction of APP was negatively correlated with the preoperative liver function.
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