J.Jpn. Surg. Soc.. 94(9): 1000-1007, 1993

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Original article

ORNITHINE DECARBOXYLASE (ODC) ACTIVITY IN THE MUCOSA OF HUMAN REMNANT STOMACH, AND THE CLINICAL SIGNIFICANCE ON TUMOR PROMOTION

Ornithine Decarboxylase (ODC) is the most important and rate-determining enzyme in the biosynthetic pathway of polyamines which have received attention as potential indicators for neoplastic diseases. Here I report my results of the ODC activity in biopsy specimens of the mucosa from the remnant stomach in 45 cases followed closely within twenty years after the initial gastrectomy.
I found that the mucosa at the amastomotic region showed higher ODC activity than that from any other region (p＜0.01). In all 20 cases which had undergone reconstruction Billroth II, the mucosa at the anasomotic region showed higher ODC activities than from the 20 cases which had undergone Billroth I (p＜0.05). Furthermore, the mucosa after Billroth II showed a gradually increasing mean ODC activity with time.
Histologically, If ound atrophy of the glands with foveolar hyperplasia more in the anastomotic region than in any other part of the remnant stomach (p＜0.001) and more so in those cases of Billroth II.
These results suggest mucosal ODC activity may be a useful and effective biological indicator of the risk of carcinogenesis in the human remnant stomach.

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