J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 391KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 94(6): 615-620, 1993

Original article

LYMPHOCYTE SUBSETS AND INTERLEUKIN-2 RECEPTER IN BREAST CANCER PATIENTS

1) Department of Surgery, St. Marianna University School of Medicine, Toyoko Hospital , Kawasaki, Japan
2) First Department of Surgery, St. Marianna University School of Medicine, Kawasaki, Japan

Hiroyoshi Yokose1), Hiroyuki Komoriyama1), Osamu Akaishi1), Masamichi Morikubo1), Toyota Yamanaka1), Susumu Yamaguchi1), Kenji Katayama2)

The lymphocyte subsets and IL-2R (p55/Tac) in breast cancer patients were analyzed using monoclonal antibody and flow cytometry until 6 post-operative month.
Results were as follows:
1. Lymphocyte fraction of CD3, 4, 8 was maintained from pre-operative to post-operative 6 month. 2. IL-2R value was lower in recurrence group than in breast bening disease group and it was lower. In pre-operative IL-2R in Stage Ill group than in Stage I and, Stage II. It was lower in DNA aneuploidy group than in DNA diploidy group. 3. At the post-operative 6 month, IL-2R was higher in Stage III group, ly-factor positive group, v-factor positive group and DNA aneuploidy group than in recurrence group. When breast cancer recurred after resection, IL-2R value returned to initial value. In conclusion, IL-2R may be possibly one of the factors of recurrence of breast cancer.

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