J.Jpn. Surg. Soc.. 93(8): 833-841, 1992

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Original article

INVESTIGATION OF LIPIDPEROXIDATION IN REGENERATING RAT LIVER

The purpose of this study was to estimate the effects of lipid peroxidation in regenerating rat liver. Partial 70% hepatectomy was performed in rat according to Higgings and Anderson. EPC (α Toc : Ascorbic acid=6:4, radical scavenger) was injected intravenously (5mg/kg weight) one hour before operation. Lipid peroxidation in regenerating liver reached a peak at 24 hours after operation. The administration of EPC markedly suppressed the increase of lipid peroxide in the plasma and remnant liver and that of GPT after hepatectomy, with subsequent good liver regeneration ratio. Moreover, the pretreatment with EPC remarkably elevated the activity of tymidine kinase (index of DAN synthesis). The EPC administration had not notable effects on the level of plasma keton body ratio in animal but pathologically caused early advent of glycogen granule in the remnant liver tissue after partial hepatctomy, which reflected restoration of mitochondrial energy leve.
The results of the present study suggest that scavenger may be useful not only for impairment of liver dysfunction but also for recovery of mitochondrial energy level and DNA synthesis after liver resection.

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