[
Abstract]
[
Full Text PDF] （in Japanese / 5179KB）
[Members Only And Two Factor Auth.] J.Jpn. Surg. Soc.. 93(6): 599-606, 1992
Original article
HISTOPATHOLOGICAL FINDINGS IN RECTAL CARCINOMAS UNDERGOING PREOPERATIVE IRRADIATION COMBINED WITH CHEMOTHERAPY
To evaluate the utility of preoperative irradiation（42.6 Gy）for rectal cancer, we examined histological specimens of surgically resected tumors, which were treated with（36 cases）or without（39 cases）preoperative irradiation. On the basis of the histological findings, irradiated cases were classified into non-effective group（17 cases）and effective group（19 cases）. According to quantitative anlaysis, cancer gland ratio（CGR）was 31.3％ in non-irradiated group, 16.6％ in non-effective group and 3.6％ in effective group, while fibrosis ratio was 19.9％, 34.4％ and 38.6％, respectively. The radiotherapy significantly reduced cancer gland and induced fibrosis. Influencing factors of recurrence in rectal cancer, such as depth of invasion, ew, vessel invasion（ly, v）and lymph node involvements were improved in the irradiated group, especially in effective cases, as compared with the non- irradiated group. In conclusion, preoperative irradiation therapy was thought to contribute to control of l㏄al recurrence and result in improvement of survival rate by decreasing several risk factors.
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