J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 5219KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 93(4): 419-428, 1992

Original article

DEVELOPMENT OF A METHOD TO PREVENT DEGENERATIVE CHANGES OF THE VEIN GRAFT FOR ARTERIAL RECONSTRUCTION

1) Second Surgical Department, Kyoto Prefectural University of Medicine, Kyoto, Japan
2) Cardiopulmonary Surgery, Research Division University Hospital of Groningen, Groningen, the Netherlands

Shinichi Sato1), Satoshi Niu1), Keiichi Kanda1), Takahiro Oka1), Ch. R.H. Wildevuur2)

Autologous vein graft is frequently used for arterial reconstruction in vascular sargery. Its' long-term patency rate, however, is low because of the degenerative changes of the vein wall. Of the basis of our hypothesis that the degenerative changes are mainly caused by an over-distension of vein wall in arterial system, in this study, autlougous vein grafts of rabbit (N＝56) were implanted in the carotid arteries. To perevent overdistension, some of the grafts were covered with prosthesis which was made of microporous, compliant biodegradable polyurethane and were compared with those without prosthesis. The integrity of the architecture of the vein wall covered with prosthesis was well preserved at 6 weeks after implantation, where the biodegradation of prosthesis induced an optimal arterialization of the vein grafts. The results indicate that this method may prevent the degenerative changes of vein wall such as fibrosis and intimal hyperplasia, which would cause poor long-term patency of vein graft used for arterial reconstruction.

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