J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 651KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 93(4): 345-351, 1992

Original article

METABOLIC EFFECTS OF GFX + BCAA SOLUTION IN THE OLD AGED RATS AFTER OPERATION

First Department of Surgery, Kobe University School of Medicine , Kobe, Japan

Makoto Usami, Harumasa Ohyanagi , Hiroshi  Kasahara, Yoichi  Saitoh

Effects of total parenteral nutrition (TPN) on the perioperative metabolism in old aged rats were evaluated. Extremely old rats (over 100 weeks old) and young rats undergoing laparotomy were treated with TPN (200ml/kg/days, 182cal/kg/day, 148 nonprotein cal/N ratio) consisting of carbohydrate mixtures (combination of glucose, fructose, and xylitol, 4:2:1 GFX solution) and 10% amino acids solution with 30% of branched chain amino acids (BCAA). Blood, liver, and urine samples were analyzed on 1, 3 postoperative days.
Increased body weight, positive balance in daily nitrogen excretion, and decreased water content of the liver were observed in old rats. Protein, glycogen, and triglyceride contents of the liver tissue increased in old rats. However the young rats showed negative nitrogen balance and stronger catabolic effect than the old rats. It suggested negative nutritional balance in young rats with this decreased dosage of GFX + BCAA solution suitable for the old rats. In conclusion, decreased amounts of GFX + BCAA solution improved perioperative metabolism in the extremely old.

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