J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 4282KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 92(12): 1678-1685, 1991

Original article

CATABOLISM OF LIPOPROTEIN-X (Lp-X) INDUCED BY INFUSION OF 10% INTRALIPID

First Department of Surgery, School of Medicine, Chiba University, Chiba, Japan

Mikio Abe, Tsuguhiko Tashiro, Yoshiya Mashima, Hideo Yamamori, Masahiko Nishizawa, Masao Sanada, Katsuji Okui

In order to clarify the metabolism of Lipoprotein X (Lp-X) induced by intravenous Intralipid 10%, in vitro experiments using purified Lp-X from the sera of the patients receiving Intralipid 10% were carried out.
1) Lp-X or high density lipoprotein (HDL) was incubated with J-774 macrophages laden with [3H] cholesterol. Marked extraction of cholesterol from macrophages by Lp-X as well as HDL was observed.
2) [3H] cholesterol labelled Lp-X or oxidized LDL (o-LDL) was incubated with J-774 macrophages. Incorporation of Lp-X into macrophages was negligible comparing to o-LDL.
3) [3H] cholesterol labelled Lp-X, low density lipoprotein (LDL), or HDL was incubated with Hep G2 cells was less than LDL, but similar to that of HDL.
These results indicated that Lp-X extracted cholesterd from peripheral tissues during its formation , and it was not catabolized by the scavenger pathway, but catabolized by the LDL pathway of hepatocytes.

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