J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 2024KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 92(9): 1307-1311, 1991

Report on the annual meeting

TREATMENT OF HEPATOCELLULAR CARCINOMA FROM THE ASPECT OF NUCLEAR DNA ANALYSIS

First Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan

Jiro Fujimoto, Eizo Okamoto, Naoki Yamanaka, Takeshi Oriyama, Kazutaka Furukawa, Eisuke Kawamura

Flow cytometric DNA analysis was done on 302 resected hepatocellular carcinoma and 30 specimens by fine needle aspiration biopsy. Patients with DNA aneuploid tumors had a significant worse prognosis than those with DNA diploid tumors in subdivided groups by curability (p＜0.01). The recurrence after hepatectomy occurred frequently in DNA aneuploid or non-curative resected group. In a cox multivariate analysis, nuclear DNA content provided significant prognostic value (p=0.008) as did vascular invasion and intrahepatic metastasis. For the multiple tumors of hepatocellular carcinoma, it is helpful to get the DNA ploidy pattern to diagnose tumors with intrahepatic metastasis or multicentric origin. Nuclear DNA analysis by fine needle aspiration biopsy was useful to determine the treatment method of hepatocellular carcinoma.

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