J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 1467KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 92(9): 1304-1306, 1991

Report on the annual meeting

IMMUNOLOGICAL ASSESSMENT OF THE PATHOGENESIS OF SEPTIC-MOF: RELATIONSHIP BETWEEN COMPLEMENT ACTIVATION AND CHANGES IN NEUTROPHIL FUNCTIONS

1) First Department of Surgery, Kyushu University School of Medicine, Fukuoka, Japan
2) Department of First Surgery, Fukuoka University School of Medicine, Fukuoka, Japan

Tomomochi Goya1), Fukashi Doi1), Takashi Morisaki1), Motomichi Torisu1), Hidehiko Shimura2)

We investigated the pathogenesis of septic-MOF through the relationship between changes in neutrophil functions and degree of complement activation. The patients’ neutrophils exhibited enhanced adherence to HUVEC, suppressed chemotaxis toward C5a, enhanced production of oxygen radicals and lysosomal enzymes. These changes in neutrophil functions related to complement activation elicited via classical pathway. Moreover, the activated complement participated in tissue injuries due to the cytolytic action of the terminal complement complexes such as membrane attack complex (MAC). In conclusion, the combination of neutrophil and complement was strongly associated with the pathogenesis of the septic-MOF.

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