J.Jpn. Surg. Soc.. 92(9): 1163-1166, 1991
Report on the annual meeting
EXPERIENCE OF MULTIMODAL THERAPY FOR ADVANCED NEUROBLASTOMA
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1) The First Department of Surgery, School of Medicine, Nihon University, Tokyo, Japan Mitsumasa Iwata1), Ikuo Okabe1), Tsugumichi Koshinaga1), Noriyuki Hagino1), Ken Morita1), Hideo Mugishima2), Rikisaburo Kamata3) |
Elevated serum NSE and ferritin level and unfavorable histology according to the Shimadas histological classification, all of which are indicators of poor prognosis, were found in all of them. N-myc oncogene was amplified in 3 cases. After preoperative intesive induction chemotherapy, delayed primary operation and intraoperative irradiation (10－15 Gy) were performed. The postoperative lethal dose chemotherapy and total body irradiation (33 Gy×3 days) were followed by autologous bone marrow transplantation. Tumor cells were purged using immunomagnetic beads method. Two cases showed recurrence (brain ; 1, bone and bone marrow ; 1) and a metastatic brain tumor was extirpated completely. All of them are alive during the follow up period from 6mo. to 4y8mo. (mean ; 2y5mo.) with no evidence of disease except one. It may be concluded that our multimodal therapy is effective in achieving better results for advanced neuroblastoma.
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