J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 1963KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 92(9): 1151-1154, 1991

Report on the annual meeting

THERAPEUTIC APPROACH AND ASSOCIATED PROBLEMS OF ADVANCED LIVER TUMORS IN CHILDREN BASED ON NUCLEAR DNA PLOIDY PATTERN

1) First Department of Surgery, Hokkaido University School of Medicine, Sapporo, Japan
2) Department of Surgery, Sapporo National Hospital, Sapporo, Japan
3) Department of Surgery, Hokkaido Children's Hospital and Medical Center, Otaru, Japan

Yoshinobu Hata1), Kazuyoshi Omori1), Hiromasa Takahashi1), Fumiaki Sasaki1), Junichi Uchino1), Haruhiko Naito2), Takashi Kobayashi3)

We evaluated the therapeutic approach and its associated problems in 14 hepatoblastomas (HB) and 3 hepatocellularcarcinomas (HCC) based on the ploidy patterns determined from paraffin-embedded tissues by flow cytometry. Aneuploid pattern was seen more frequently in the patients with poorly differentiated and immature types of HB, and HCC. It was also observed in patients with tumors showing microscopic vessel invasion, and in patients showing resistance to the therapeutic approach. Among 4 patients with combined epitherial components of HB, 2 patients' tumors revealed both the aneuploid and diploid patterns and their prognoses were poor. The prognoses of patients with tumors showing the aneuploid pattern were significantly poorer. From our study we concluded that careful attention should be pain to the heterogeneity of these tumors and that more aggressive treatment for tumors showing aneuploid pattern should be developed.

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