J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 2014KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 92(9): 1098-1101, 1991

Report on the annual meeting

CARBOHYDRATE ANTIGENS AS A TUMOR-ASSOCIATED ANTIGEN AND PROGNOSTIC INDICATORS IN CARCINOMAS OF THE BREAST, ESOPHAGUS, STOMACH, COLORECTUM, AND PANCREAS

1) Department of Surgery II, Nagoya University School of Medicine, Nagoya, Japan
2) Department of Gastrointestinal Surgery, Aichi Cancer Center Hospital, Nagoya, Japan
3) Department of Surgery, Nagoya Nationai Hospital, Nagoya, Japan

Tadashi Watanabe1), Hideji Asai1), Junichi Sakamoto2), Tatsuhiko Narita1), Toru Ichihara3), Masashi Yamauchi1), Hiroshi Takagi1)

The immunohistochemical analysis using the monoclonal antibodies to the carbohydrate antigens were performed and suggested that CA19-9 is a tumor-associated antigen in gastric cancer, Leb, Ley, CA19-9, CSLEX1, SLX in colorectal cancer and pancreatic cancer, and Lex, Ley, and CSLEX1 in breast and esophageal cancers, respectively. Expression of the type 2 carbohydrate antigens had relation to the prognosis of patients with breast cancer. In colorectal cancer, the patients with high degree of expression of CA19-9 had a poor prognosis, and high risk of distant metastasis. Higher intensity of staining was observed in hepatic metastasis, in comparison with primary lesion. Thus carbohydrate antigens showed important role as tumor-associated antigens and good indicator for evaluation of prognosis.

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