J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 2178KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 92(9): 1090-1093, 1991

Report on the annual meeting

CANCER METASTASIS AND RECURRENCE FROM THE STANDPOINT OF AMPLIFICATION AND EXPRESSION OF ONCOGENES IN HUMAN MALIGNANT TUMORS

1) Department of Surgery, School of Medicine, Keio University, Tokyo, Japan
2) Department of Surgery, Tokyo Denryoku Hospital, Tokyo, Japan

Kiyoshi Kikuchi1)2), Masakazu Ueda1), Yuko Kitagawa1), Nobutoshi Ando1), Osahiko Abe1)

We investigated the amplification and expression of oncogenes in human malignant tumors. The survival rates of patients with c-erbB, c-erbB-2, and int-2 oncogene amplification/expression were significantly lower than those of the patients without gene amplification/expression. Many distant organ metastases were observed in esophageal cancer patients with int-2 amplification, in gastric cancer patients with c-erbB-2 over-expression, and in breast cancer patlents with int-2 and c-erbB-2 amplification. These results suggest that the amplification/expression of these oncogenes may serve as good markers for determining the biological malignancy of cancers.

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