J.Jpn. Surg. Soc.. 91(9): 1459-1462, 1990

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Report on the annual meeting

PROSTAGLANDIN E₁ （PGE₁）HAS NO INHIBITION TO THE DAMAGE OF THE CANINE INTESTINAL NERVE PLEXUSES UNDER THE HYPOXIC STATE

To clarify the ischemic intestinal damage, the PGE₁ was administrated in the canine jejunal segments, which were taken from the anesthetized dogs and cannulated in their mesenteric vessels to circulate the blood flow through the silicon membrane oxygenerator, which was supplied with 25%O₂+ 5%CO₂+70%N₂ added 5%CO₂+95%N₂ gases to maintain the normal (PaO₂ 130mmHg) and low oxygen (PaO₂ 40mmHg) condition.
Biochemical parameters, i.e. oxygen consumption, lactate and pyruvate production were measured before and after hypoxic state. After the judgement of the villus damage, histochemical staining for the intestinal nerve plexuses using an antiserum to S-100 protein, was performed to evaluate the damage to nerve cells, nerve fibers and glia cells. The results of the biochemical studies show that PGE₁ prevents the intestinal anaerobic respiration during the hypoxic state for 30 minutes. Otherwise, after 30-minute hypoxia, the nerve plexuses, especially intramuscular plexuses, were not free of ischemic changes.

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