J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 1248KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 91(9): 1456-1458, 1990

Report on the annual meeting

ROLE OF DIAMINES IN THE PATHOGENESIS OF ISCHEMIC INTESTINAL INJURY

Departments of Surgery, Kumamoto University Medical School, Kumamoto, Japan
*) Departments of Biochemistry, Kumamoto University Medical School, Kumamoto, Japan

Shuichi Koshi, Masayasu Inoue*), Hiroyuki Obayashi, Yoshimasa Miyauchi

To elucidate the role of diamines in the pathogenesis of post-ischemic reflow induced cell injury, effect of diamine oxidase was studied in the rat whose superior mesenteric artery was occluded for 15 min followed by 30 min reflow. In the study for changes of vascular permeability using isotope, when diamine oxidase was administered prior to occlusion, the increase in vascular permeability of the intestine was inhibited almost completely.
Histological examination also revealed that post-ischemic reflow induced injury of the intestine was reduced significantly by diamine oxidase. These and other results suggested that diamines and/or their metabolite(s) might predominantly be responsible for the intestinal injury caused by post-ischemic reperfusion.

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