J.Jpn. Surg. Soc.. 91(9): 1453-1455, 1990

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Report on the annual meeting

CHANGES IN SMALL BOWEL MUCOSA AFTER ACUTE ISCHEMIA AND REPERFUSION

The functional changes in small bowel mucosa, the effects of administration of allopurinol or prostaglandin E₁(PGE₁) and the effect of the intraluminal administration of perfluorochemicals on the ischemic small intestine were studied experimentally. Mucosal levels of Na⁺-K⁺-ATPase activity, glycoprotein, cyclic AMP, ATP and energy charge had decreased after ischemia and reperfusion, and mucosal levels of hypoxanthine, xanthine and uric acid had increased. However, these mucosal changes were suppressed by the administration of allopurinol or PGE₁ and by the intraluminal administration of perfluorochemicals. These results suggested that a lack of mucosal permeability and a marked disturbance of absorption and mucin synthesis occurred after ischemia and reperfusion due to the effect of free radicals produced by the oxidation of hypoxanthine. Also, we concluded that the administration of allopurinol or PGE₁ as well as intraluminal administration of perfluorochemicals was useful to prevent ischemia-reperfusion injury of the small intestine.

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