J.Jpn. Surg. Soc.. 91(9): 1421-1423, 1990

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Report on the annual meeting

REPERFUSION INJURY AND ITS REDUCTION－INSIGHTS INTO THE LIPID PEROXIDATION

It was shown experimentally that TBA, which was one of the lipid peroxidates, was generated in the myocardium by the reperfusion following the cardioplegia under the extracorporeal circulation and the cardiac function was worse in comparison with the case without cardioplegia. That is to say, the cardioplegia was accompanied with the reperfusion injury. In clinical cases, the myocardial edema was correlated to the TBA generation in the myocardium, as follows. %⊿mass=25.84×TBA release ratio+ 13.3 (r=0.416, p<0.05) %⊿mass=24.37×⊿TBA/LVmass+13.7 (r=0.441, p<0.05). The recovery ratios of the cardiac functions to the preoperative data had the negative correlation to the myocardial edema.
Under the cardioplegia, reperfusion injury of the myocardium was reduced by means of perfusing the SOD, which was the scavenger of the superoxide anion, and then favorable results were derived in every parameter. In regard to the method to dose SOD, perfusing 3mg/kg directly to the coronary system just before the reperfusion was the most effective method.

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