J.Jpn. Surg. Soc.. 91(9): 1385-1388, 1990

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Report on the annual meeting

MULTIDISCIPLINARY THERAPY OF LOCALLY RECURRENT RECTAL CANCER

Since 1981, twenty six patients received surgical removal of locally recurrent rectal cancer. To these patients, the following operations were done ; total pelvic exenteration combined with sacral resection in nine, posterior pelvic exenteration combined with sacral resection in seven, abdominoperineal resection combined with/without sacral resection in six, tumor extirpation in three, and Hartmann's operation in one patient. Of these 26 patients, 22 underwent curative resection and four non-curative resection. Five year survival rate of patients who received curative resection was 23.7% and four year disease free survival rate of them was 10.2%.
Of these 22 patients, nine received post-operative adjuvant radiotherapy and/or chemotherapy. Four year survival rate of patients with post-operative adjuvant therapy was 60.0% and it was 36.3% in patients without postoperative adjuvant therapy. There was no difference in the disease free survival rates between both groups.
Eight patients with non-resectable pelvic recurrence after surgery for rectal cancer received continuous arterial infusion of 250mg 5-FU and bolus i.a. infusion of 4mg MMC every two weeks. The responce rate for all patients was 25% (2/8) and 50% survival for all patients was 15.5 months.

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