J.Jpn. Surg. Soc.. 91(9): 1375-1377, 1990

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Report on the annual meeting

IMPORTANCE OF MULTIDISCIPLINARY TREATMENT FOR HEPATOCELLULAR CARCINOMA

The present study reports an importance of multidisciplianry treatment using 409 patients with hepatocellular carcinoma who had hepatectomy between Apr. 1973 through Dec. 1989. There was no significant difference in survival rate between 219 without preoperative transarterial embolization (TAE) and 53 with preoperative TAE. On the contrary, TAE, alone or together with intratumoral ethanol injection therapy, was very useful in prolongation of survival after intrahepatic recurrences. Ethanol injection was the first option for one to two recurrent nodules less than 3cm. Over-all disease free survival rate was only 29% at 5 years even in the curative resection group while actual survival with multidisciplinary therapies for recurrences was 59%. For the 44 advanced tumors with portal tumor thrombi or intrahepatic metastases in the contralateral lobe, reductive resection combined with hepatic arterial ligation, ethanol injection or postoperative TAE was useful strategy. The combination therapy achieved a 5-years survival rate of 8%.

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