J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 1825KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 91(9): 1268-1271, 1990

Report on the annual meeting

THERAPEUTIC EFFECT OF THE TRANSFER OF KILLER T CELLS（ADOPTIVE IMMUNOTHERAPY）AGAINST BEAST CANCER AND GASTROINTESTINAL CANCER

First Department of Surgery, Kyoto University, Faculty of Medicine, Kyoto, Japan

Norimichi Kan, Takayoshi Tobe

Local transfer of cultured killer T cells (adoptive immunotherapy : AIT) has been performed to 345 patients with advanced malignancies since 1981. Preadministration with local OK-432 has bee combined to augment the effect of AIT since 1983. CD3+ cultured lymphocytes possessing lytic activity against autologous tumor cells were obtained from Iymph-node lymphocytes, peripheral blood lymphocytes or tumor-infiltrating lymphocytes by 13 days' culture with medium containing T cell growth factor and recombinant (r-) IL2. Sonicated autologous tumor extract was useful to augment the killer activity of cultured lymphocytes.
The response rates against pleural effusion of breast cancer, liver metastasis of breast cancer, liver metastasis of stomach or colo-rectal cancer were 27/29, 15/25, 6/19, respectively. Survival rate was significantly better than historical control in the following groups;pleural effusion of breast cancer (5-year survival, 29%), liver metastasis of breast cancer (16%) and peritoneal dissemination of gastric cancer. Thus, AIT is useful as loco-regional treatment of advanced cancer.

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