J.Jpn. Surg. Soc.. 91(9): 1256-1259, 1990
Report on the annual meeting
EXPERIMENTAL AND CLINICAL EVALUATION FOR SIMULTANEOUS MAJOR RESECTION OF THE LIVER AND PANCREAS
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First Department of Surgery, Mie University School of Medicine, Mie, Japan Yoshifumi Kawarada, Takashi Noguchi, Ryuji Mizumoto |
I. Experimental study
All dogs that underwent 92% pancreatectomy alone developed diabetes, but the delayed diabetes and its frequency was reduced when pancreatectomy was carried out with hepatectomy.
The 10-week survival rate was only 25% in dogs those received 70% hepatectomy with more than 92% pancreatectomy, and many of them died of liver failure.
Long-term survival was observed in more than 60% of dogs after 70% hepatectomy with 92% or less pancreatectomy or after 40% hepatectomy with more than 92% pancreatectomy.
II. Clinical review and operative procedure
Five cases in our clinic and 241 patients collected by Mizumoto (1989) from all over Japan were reviewed.
Post-operative morbidity and mortality was higher than those of other major surgeries. However, prognosis of those patients with this operative procedure has been improved, especially in exterided two segmental hepatectomy with pancreatectomy.
Therefore, simultaneous major resection of the liver and pancreas should be performed aggressively for biliary carcinoma when the procedure is considered to be curative surgery with consideration of the quality of life.
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