J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 1936KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 91(9): 1162-1165, 1990

Report on the annual meeting

CHANGES IN SERUM CYTOKINE LEVELS AFTER SURGICAL INTERVENTION AND THE MECHANISM OF THE INDUCTION OF ACUTE PHASE REACTANTS

Second Department of Surgery, Osaka University Medical School, Osaka, Japan

Atsuo Murata, Michio Ogawa, Tadashi Yasuda, Yoshio Oka, Yoshitaka Omachi, Nobuaki Hiraoka, Takesada Mori

We measured serum immunoreactive cytokine (IL-6) levels in 23 patients after various surgeries and compared them with changes in serum acute phase reactants (CRP, PSTI). Serum IL-6 levels were elevated postoperatively 1ー2 days earlier than serum CRP or PSTI, and the degree of the elevation of IL-6 was significantly correlated with the intensity of surgical intervention. There were also significant relationships between the peak levels of serum IL-6, CRP and PSTI. In vitro study revealed that the release of PSTI from cultured human hepatoma cells were increased with the stimulation of IL-6 in a dose dependent manner.
These results suggested that the early increase of postoperative serum IL-6 might be a useful laboratory marker reflecting the severity of surgical intervention, and that the induction of acute phase reactants could be caused by the elevated serum IL-6.

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