J.Jpn. Surg. Soc.. 91(9): 1154-1157, 1990

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Report on the annual meeting

ARTIFICIAL ORGANS IN MODERN SURGERY

In the early 20th century, A. Carrel commenced a pioneering work in vascular surgery, such as blood vessel anastomosis and replacement using various tube prostheses, and applied it to organ transplantation. If he is called the grandfather of artificial organs, W. Kolff could be called the father of artificial organs in the later 20th century.
In Japan, in 1950, my teacher S. Kimoto studied 70% alcohol-preserved allo- and xeno-aorta as a biograft for aneurysm replacement. This was the first artificial organ study in Japan.
In 1957, the author introduced a new concept of bio-artificial (or hybrid artificial) organ in realizing the biological artificial liver using a cross-hemodialysis between four live dogs' hepatic circulation and systemic circulation of the patient with hepatic coma.
Since then, various cardiovascular, renal, metabolic and other artificial organs have been developed and applied in the field of modern surgery, which have opened a new domain in future surgery together with organ transplantation.
In the coming century, artificial organs will be more promising than organ transplantation, which will encounter with much restriction even in future, in playing more important role in organ substitution.

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