J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 4340KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 91(8): 931-941, 1990

Original article

EFFECTS OF THE SYNTHETIC PROTEINASE INHIBITOR, FOY, ON HYPERCOAGULABILITY AFTER SURGERY FOR ESOPHAGEAL CARCINOMA

First Department of Surgery, Fukushima Medical College, Fukushima, Japan

Akira Usuba, Ryoichi Motoki, Yuko Koizumi, Akio Oishi, Yukio Endo, Osamu Konno, Hitoshi Inoue

Hypercoagulability develops after surgery for esophageal carcinoma, and it related closely to postperative complications. This study evaluated the effects of the synthetic proteinase inhibitor, Cabexate Mesilate (FOY), on this hypercoagulability. The subjects used were 25 patients with a mean age of 63 who had undergone surgery for esophageal carcinoma. Of these, eight patients (test group) received FOY (2,000mg/day) for three to 23 days after surgery, but 17 (control group) did not. In the test group, FOY controlled aggregation and release of the platelets and minimized their exhaustion. FOY almost completely checked the abnormal increase in thrombin activity which might trigger the hyper-coagulability. Also, FOY suppressed the fibrinolytic activity slightly. These results indicate that FOY is effective in controlling hypercoagulability after surgery for esophageal carcinoma and in suppressing activity of the proteinases that cause both blood coagulation and fibrinolysis.

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