J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 1179KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 90(12): 1955-1958, 1989

Original article

EFFECT OF UFT ON NUCLEAR DNA DISTRIBUTION OF GASTRIC AND COLORECTAL CARCINOMAS

The 2nd Dep. of Surgery, School of Medicine, Kanazawa University, Kanazawa, Japan

Takeo Kosaka, Shigeru Takegawa, Shigekazu Oyama, Akio Yamaguchi, Yutaka Yonemura, Koichi Miwa, Itsuo Miyazaki

To evaluate the effect of UFT on nuclear DNA distribution of carcinoma, we measured the DNA content of biopsy specimens and resected specimens obtained from 18 patients by microfluorometry. The tumors consisted of 7 gastric and 11 colorectal carcinomas. Five patients who received administration of 400mg of UFT (400mg of tegafur) were classified as the chemotherapy group and another 13 patients were classified as the control group.
1) DNA indices of biopsy specimens and resected specimens of the same patients showed almost the same values both in the control group (r=0.81) and in the chemotherapy group (r=0.89)(p＜0.05).
2) S and S+G2M fractions of resected specimens showed almost the same values as compared with those of corresponding biopsy specimen in the control group. However, in the chemotherapy group S and S+G2M fractions of resected specimens showed a tendency to be higher than those of corresponding biopsy specimen (0.05＜p＜0.1).
This study indicates that the biopsy specimens are sufficient for DNA analysis and that UFT-induced DNA change may be increase of S and S+G2M fraction.

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