[
Abstract]
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Full Text PDF] （in Japanese / 1181KB）
[Members Only And Two Factor Auth.] J.Jpn. Surg. Soc.. 90(9): 1568-1570, 1989
Report on the annual meeting
NUCLEAR DNA ANALYSIS OF HEPATOCELLULAR CARCINOMA
Retrospective DNA ploidy studies of paraffin-embedded blocks were performed by flow cytometry on 212 surgically resected hepatocellular carcinoma. One hundred and sixty-four of 212 specimens yielded evaluable DNA histograms. Eighty-three cases showed a DNA diploid pattern and 81 a DNA non-diploid pattern. The incidence of non-diploid pattern increased with the tumor size. (2cm ; 15.4％, 2－5 ; 42.3％, 5－10 ; 70.8％＞10 ; 73.3％). The DNA pattern correlated with the backgrounds, the degree of vascular invasion, intrahepatic metastasis and serum AFP levels. Survival of patients with non-diploid pattem was significantly less than those with diploid patients in any different stage. Of thirty who survived three years with disease free condition, 20 patients showed diploid patterns. Though remaining 10 patients were non-diploid patterns, 9 were high DNA index more than 1.5. It is concluded that fiow cytometric DNA ploidy study had prognostic value for patients with surgically resected hepatocellular carcinoma.
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