J.Jpn. Surg. Soc.. 90(9): 1559-1563, 1989
Report on the annual meeting
CLINICAL SIGNIFICANCE OF MEASUREMENT OF NUCLEAR DNA CONTENT IN BREAST CANCER
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Department of Surgery, Osaka Medical College, Takatsuki, Japan Takashi Nishi, Kunio Okajima, Tadahiro Taguchi, Toshio Ryo, Tadashi Sekimoto |
Many cases of D type (diploid type) which had a prominent peak at the 2c region (control DNA content of lymphocytes) were safe indicatins for modified radical mastectomy. Bone recurrence was significantly more frequent in D type than in N type (non-diploid type) which did not have a prominent peak at the 2c region. Because D type had high positive rate of hormone receptors, endocrine therapy might be effective for many cases. Local or lung recurrence was more common in cases with N type which had a significant low cumulative survival rate compared with D type and especially N type 4c-3 of which over 4c cells more than 30％ had the poorest prognosis. Therefore, multidisciplinary treatment composed of extended operation, radiation and chemotherapy was necessary to improve the prognosis of breast cancer patients with N type 4c-3.
It was concluded that the measurement of nuclear DNA content in breast cancer might be useful for decisin of therapy suitable for each case based on malignancy grading.
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