J.Jpn. Surg. Soc.. 90(9): 1439-1442, 1989

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Report on the annual meeting

THE EFFECT OF ENDOSCOPICAL INTRATUMORAL INJECTION OF OK-432IN GASTRIC CARCINOMA

Many BRMs (biological responce modifiers) have been used for post-operative immunochemotherapy. And their usefulness were also reported. Nevertheless it is still unknown that which route, how much dosis and which timing are the most effective to administrate these drugs. We used BRMs intratumorally and preoperatively.
To reconfirm the efficacy of intratumoral injection therapy randomized study was performed in gastric carcinoma. Three hundred and ninty-five cases were entried, 199 cases in group A which were treated preoperatively with OK-432 intratumorally and 196 cases in group B which were control, respectively. In the cases which had marked infiltration of lymphoid cells in tumor sites, the two year survival rate of group A was significantlly better than that of group B (p＜0.05). On the study of recurrent forms, the distal lymph node metastasis was markedly decreased in group A. The ratio of metastasis to the distal lymph nodes in group A was 5－10％ lesser than that in group B on the each depth of tumor invasion. The ratio of lymph nodes metastasis was almost similar in the each group, but the number of metastatic lymph nodes was significantlly reduced in high grade tumor infiltrated cases in group A (p＜0.005).
These results suggest that preoperative endoscopically intratumoral administration of OK-432 supresses the lymph node metastasis and improves the postoperative survival rate.

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