[
Abstract]
[
Full Text PDF] （in Japanese / 2213KB）
[Members Only And Two Factor Auth.] J.Jpn. Surg. Soc.. 90(9): 1366-1369, 1989
Report on the annual meeting
THE ROLE OF OXYGEN FREE RADICAL AND FREE RADICAL SCAVENGER IN SEPTIC AND HEMORRHAGIC SHOCK
The roles of oxygen free radical (O
2-), lipoperoxide (LPO) and free radical scavenger were clinically and experimentally studied in septic and hemorrhagic shock. The reduction of hepatic tissue blood flow (TBF) were equalized in two groups (40-55％ of normal level) and rats were subdivided into 3 groups : untreated, normal saline (NS) continuous IV and superoxide dismutase : SOD+catalase (S/c) continuous IV as free radical scavenger. The change of TBF, destruction of mitochondrial structure and elevation of LPO were prevented by S/c in Et shock. No significant effect by S/c was observed in hemorrhagic shock. The neutrophil derived O
2- was markedly elevated in Et shock animals as well as septic shock patients but no significant change was noted in hemorrhagic shock animals or non septic shock patient. SOD and catalase were effective for neutrophil derived O
2- in septic shock whereas little beneficial effect was noted in hemorrhagic or non septic shock.
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