J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 3861KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 90(4): 586-597, 1989

Original article

THE INFLUENCE OF TRUNCAL VAGOTOMY OR SURGICAL SYM-PATHECTOMY ON THE PANCREATIC TROPHIC EFFECT OF TRYPSIN INHIBITOR UPON NORMAL RATS AND MAJOR PANCREATECTOMIZED RATS

The 1st Department of Surgery, Faculty of Medicine, Kyoto University, Kyoto, Japan
*) The 2nd Department of Surgery, Faculty of Medicine, Yamaguchi University, Ube, Japan
**) Department of Surgery, Kokuryo Minami Kyoto Hospital, Kyoto, Japan

Toshihiko Aki, Nobuo Baba, Takayoshi Tobe, Takashi Suzuki*), Ichiro Nishimura**), Genkei Tsai**)

The influences of truncal vagotomy or surgical sympathectomy on the pancreatic trophic effect of oral administration of synthetic trypsin inhibitor (FOY-305) were examined upon normal rats and 85% major pancreatectomized rats. On normal rats, oral administration of trypsin inhibitor increased pancreatic weight, DNA content RNA content, protein content, pancreatic weight/DNA, RNA/DNA and protein/DNA. This pancreatic trophic effect seemed to be consisted of hyperplasia and hypertrophy of pancreatic acinar cell. Under truncal vagotomy or surgical sympathectomy, this trophic effect was not diminished. On major pancreatectomized rats, oral administration of trypsin inhibitor also caused pancreatic trophic action, consisted of hyperplasia mainly. And truncal vagotomy or surgical sympathectomy did not decrease this action. These results suggested that oral administration of trypsin inhibitor might be a beneficial method for functional recovery of remnant pancreas after major pancreatectomy even under the denervated state.

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